Objective: This study was to investigate the correlation between serum CRP levels and ferritin in patients with chronic heart failure.

Methods: This study is a cross-sectional study. We investigated 210 patients with heart failure who attended the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Xinjiang Medical University from December 2023 to February 2025. Comparison of iron parameters between different ultrasensitive C-reactive protein quartiles was made.

Results: The highest quartile group (Q4) of ultrasensitive C-reactive protein had significantly higher serum ferritin levels than the first (Q1) second (Q2) and third (Q3) quartile groups, Q1 [133.7 (88.4, 204.8)],Q2 [129.0 (77.1, 256.8)],Q3 [121.3 (58.7, 189.5)],Q4 [202.0 ( 106.3446.2)], p < 0.05.

Conclusion: Ferritin levels in patients with chronic heart failure are influenced by a number of factors in their condition, and the use of ferritin may overestimate the iron status of patients with chronic heart failure.

The objective of this study was to evaluate the anticancer effects of Gloydius brevicaudus venom (GBV), a natural bioactive substance, on lung cancer through in vivo and in vitro experiments, and to explore its mechanism of action. Methods included measuring the inhibition rate with the CCK-8 assay, detecting cell apoptosis via flow cytometry, and analyzing the expression of apoptosis-related proteins by Western blot. A nude mouse xenograft model was established, with intratumoral injection as the administration route, administered every two days. The therapeutic effect of GBV on the xenograft model was observed, and immunohistochemical analysis was performed to detect the expression of tumor proliferation marker Ki-67 in the nude mice. The results from in vitro experiments showed that GBV exhibited cytotoxicity against tumor cells and induced apoptosis. GBV significantly upregulated the expression of proteins Bax, Cleaved-Caspase-3, Cleaved-Caspase-8, and Cleaved-Caspase-9 (P<0.05), while downregulating the expression of protein Bcl-2 (P<0.05). In vivo results demonstrated that medium and high concentrations of GBV significantly inhibited the growth of A549 tumor xenografts in nude mice. Immunohistochemical analysis showed that GBV at medium and high concentrations significantly reduced the expression level of Ki-67 in vivo. In conclusion, GBV can inhibit proliferation and induce apoptosis in A549 cells in vitro through both the mitochondrial pathway and death receptor pathway. In vivo, GBV significantly inhibits the growth of A549 xenografts and regulates tumor cell cycle and proliferation.

The theory of "Earth Pivot Four Elephants, One Qi Circulation" was initially proposed by Huang Yuanyu, a royal physician in the Qing Dynasty. It emphasizes the central role of the spleen and stomach in the middle burner as the pivot, with the liver and lungs serving as the wheels of the four elephants. This theory highlights that the healthy movement of middle qi ensures the smooth circulation of qi, allowing clear yang to rise and turbid yin to descend. Based on this theory and the holistic view of "Earth Pivot Four Elephants," this article posits that dizziness arises from the deficiency of the middle earth, the failure of the pivot to rotate, leading to liver stagnation, wind disturbance, lung stagnation, turbid reversal, and the loss of nourishment to the clear orifices. Clinically, the focus should be on strengthening the middle burner, restoring the pivot's function, and regulating the liver and lungs to harmonize the ascending and descending movements, thereby achieving coordinated wheel and pivot movements and the smooth circulation of qi. This approach aims to provide new insights for the clinical treatment of dizziness.

Objective: The Delphi questionnaire was used to evaluate and analyse 109 symptoms of 8 categories in the pool of Chinese medical evidence of tumours, and was used to formulate the "Tumour Disease Mechanism Evaluation Scale", with the aim of establishing a unified and standardized criterion for the clinical diagnosis of tumours. Methods: The questionnaire content of the "Eight Methods of Tumour Disease Mechanisms" was formulated by collating disease entries through literature review. Experts' opinions were collected through the Delphi method, and the degree of coordination and concentration of experts were statistically analysed after the collection. Results: Through two rounds of Delphi questionnaire analysis, experts' enthusiasm was 100%, the authority coefficient of the first-level index was 0.685, the second-level index was 0.065 and 0.593, and six indexes with poor correlation were deleted. Conclusion: The experts participating in this survey are representative, with high motivation and good coordination of their opinions on the questionnaire entries, and the "Tumour Disease Mechanism Identification and Evaluation Scale" formulated using this questionnaire has practical value.

Parkinson's disease is a complex degenerative disease of the elderly nervous system, and its non-motor symptoms are important factors affecting the life and family of patients with Parkinson's disease. Clinically, constipation, anxiety and depression, sleep disorders and cognitive dysfunction are the main factors, which have a profound impact on patients' daily life and work. Moreover, non-motor symptoms sometimes appear earlier than motor symptoms, so early diagnosis and treatment are required. It has important implications for Parkinson's disease. However, the pathogenesis and pathological process of non-motor symptoms are still unclear. This article aims to provide ideas for the clinical diagnosis and treatment of non-motor symptoms of Parkinson's disease from the perspective of renal treatment.

OBJECTIVE: This study aimed to uncover potential targets and mechanisms for the treatment of abnormal uterine bleeding through a network pharmacological study of Erzhi Pills

METHODS: Network pharmacology was used to predict the active ingredients and potential targets for abnormal uterine bleeding of Erzhi Pill, and the binding affinity was explored using molecular docking techniques. The relevant associated signalling pathways were studied using GO and KEGG enrichment analysis.

RESULTS: Based on the network pharmacology results, two key active ingredients, Acetin and Kaempferol, were screened, and three potential therapeutic targets, TP53, TNF, and AKT1, were screened using STRING and PPI networks. The enrichment analysis showed that these potential therapeutic targets were mainly involved in signalling pathways related to metabolism and inflammation. The binding was observed using the molecular docking technique, and both active ingredients and potential targets showed good affinity.

CONCLUSION: This study contributes new research evidence on the potential mechanism of Erzhi Pill in the treatment of abnormal uterine bleeding. The results of both network pharmacology and molecular docking techniques suggest a potential therapeutic effect of Erzhi Pill on abnormal uterine bleeding. However, these results need to be further investigated to provide more profound clinical information.

Based on the theory of "mutual nourishment between the spleen and kidney," this paper explores the regulatory mechanisms of the spleen and kidney in the menstrual axis under Traditional Chinese Medicine (TCM) theory. It systematically discusses the core role of the Spleen and Kidney-Tian Gui-Chong Ren-Uterus axis in the physiology and pathology of female menstruation. By reviewing classical TCM literature and modern research findings, the paper argues for the synergistic regulation of the spleen and kidney on the production of Tian Gui(Gate of Life), the controlling and replenishment of Thoroughfare-Conception Vessels, and the storage and discharge functions of the uterus. Combining modern research on the neuro-endocrine reproductive axis, the paper elucidates the functional connections between the spleen-kidney theory and the hypothalamic-pituitary-ovarian (HPO) axis. It also summarizes the experiences of ancient and modern physicians in treating menstrual disorders from the perspective of the spleen and kidney, aiming to provide new insights for the exploration and application of the female menstrual axis in modern TCM and to offer references for the clinical diagnosis and treatment of menstrual disorders.

Knee osteoarthritis (KOA) is the most common degenerative disease of articular cartilage in clinic.Non steroidal drug resistance（NSAIDs） has been controversial in recent years due to its serious side effects.Traditional Chinese medicine has been widely used in the treatment of KOA due to its advantages of small adverse reactions, good effect and low cost.Reports of traditional Chinese medicine related to the treatment of KOA are increasing.And a lot of research has been carried out on the mechanism of action.This article reviews the clinical application and related mechanisms of “Qin medicine” in the treatment of KOA.To provide clinical basis and theoretical basis for the application of KOA Chinese medicine in the treatment of “Qin medicine”.

This essay examines the legal and ethical challenges associated with the management of mentally ill offenders in Australia, particularly in the context of crimes committed post-release from psychiatric care. Through a case analysis of Joe Bloggs, a mentally ill individual who committed homicide after being discharged from a psychiatric facility, the paper highlights systemic failures in treatment, supervision, and risk assessment. The analysis also discusses the legal responsibilities of healthcare providers, guardians, and law enforcement, focusing on issues such as criminal responsibility, fitness to stand trial, and compensation for mental damage. Key recommendations include enhancing rehabilitation, improving interagency communication, increasing funding for mental healthcare services, and developing clearer sentencing guidelines. This comprehensive approach aims to balance public safety with humane treatment for mentally ill offenders, addressing the complexities of mental illness in the criminal justice system.

Climate change in Australia is a critical issue that impacts ecosystems, water resources, biodiversity, and the economy. The nation faces increasing challenges, including frequent droughts, rising bushfires, and sea-level rise. Australia's reliance on natural resources, particularly in agriculture, amplifies the effects of climate change. To address these concerns, Australia has implemented various strategies, such as introducing climate change legislation, establishing carbon trading markets, and committing to international agreements like the Kyoto Protocol and the Paris Agreement. This paper examines how Australia's climate laws, litigation approach, and market mechanisms work together to mitigate climate change impacts. The paper explores the role of international climate law in shaping domestic policies and emphasizes the growing trend of climate change litigation in Australia, which has had significant effects on environmental law. Additionally, the paper discusses the market mechanisms, including taxation, trading schemes, and subsidies, that drive Australia's efforts to reduce greenhouse gas emissions. In conclusion, a multidisciplinary approach combining legal frameworks, litigation, and market-based policies is essential for addressing climate change, ensuring sustainable development, and enhancing Australia's resilience to future climate impacts.

Wolbachia pipiens is an intracellular symbiotic bacterium widely found in arthropods and nematodes. Its symbiotic and mutualistic relationships with hosts have become a representative subject in symbiotic biology research. Recently, Wolbachia has also been studied for its application in controlling human and crop diseases. This review describes the natural infection of mosquitoes by Wolbachia and further summarizes research progress on suppressing mosquito populations through artificially induced Wolbachia infections. It elucidates the molecular mechanisms of cytoplasmic incompatibility induced by Wolbachia and outlines future directions for biological control of mosquito-borne diseases based on combined SIT (Sterile Insect Technique) and IIT (Incompatible Insect Technique) strategies. Additionally, the review highlights advancements and prospects in the study of controlling mosquito-borne diseases.

OBJECTIVE

To evaluate the renal function and percent improvement in the antero-posterior diameter (PI-APD) outcome in different operation age for ureteropelvic junction obstruction (UPJO) with antenatal diagnosed .

PATIENTS AND METHODS

* A retrospective review cases that under 3 years who underwent pyeloplasty from 2011 to 2015 for UPJO with prenatally diagnosed in single centre. All patients were underwent and recorded renal ultrasonography and diethylene triamine pentaacetic acid (DTPA) scans for preoperative and postoperative. Anderson-Hynes dismembered pyeloplasty was carried out for all cases.

* Records were evaluated with respect to age at operation, preoperative antero-posterior diameter (APD),  preoperative split renal function（SRF）and postoperative course.

*Considered the PI-APD>40% or SRF was improved by >5% whose underwent pyeloplasty is improvement, analyzed improvement and un-improvement patients' age.

RESULTS

* In the period 2011 to 2015, 49 cases aged <3 years of prenatally diagnosed UPJO underwent dismembered pyeloplasty with clinic date completion in our centre.

* Of these patients, male (n=46, 94%) and female (n=3, 6%) were in our study, from 1 month to 36 month, with the median age of 3.8 months. Follow-up time ranged 6 to 12 months.

* A statisitically significant different between before and after operation APD(P=0.000) or SRF(P=0.046) under the Wilcoxon rank sum Tests. There was a significant negative correlation between the age of surgery and PI-APD (R=-0.340, P=0.017). And significant negative correlation were observed between the age and improvement SRF>5% ( R=-0.382, P=0.007)

* 5 patients underwent redo double –J stent cathelerization because hydronephrosis aggravate in follow-up. The overall success rate was 89.7%.

CONCLUSIONS

* The age of pyeloplasty maybe a factor to outcome for spilt renal functional and PI-APD.

* Once a UPJO patient has a operation indication , allow appropriate early time for under surgery intervence is necessary.

Cultivated land is the basis of food production. Reasonable planning of cultivated land is crucial to increase food production, optimize resource utilization and maximize the economy. With the acceleration of global population growth and urbanization, cultivated land resources are becoming increasingly tense. Therefore, scientific planning of cultivated land can improve land use efficiency, ensure food supply, and prevent soil degradation and environmental pollution. In addition, reasonable cultivated land planning can also promote the improvement of agricultural productivity, increase farmers ' income, and provide stable food security for national economic development. Through literature review, this paper discusses the application of robust optimization technology in crop planning, and establishes a mathematical model based on actual data, aiming to provide sustainable farming schemes for rural agriculture. In the design process, we comprehensively considered the economic benefits, land fertility and crop diversity, and finally came up with a set of farming programs that can meet the needs of farmers and contribute to ecological protection to promote the healthy development of the rural economy.

This paper discusses the latest therapeutic developments and comprehensive approaches to treating IgA nephropathy (IgAN), the most common form of primary glomerulonephritis globally.   The review begins by outlining the pathogenesis of IgAN, emphasizing the "multi-hit" hypothesis, where aberrantly glycosylated IgA1 (Gd-IgA1) molecules, autoantibodies, and immune complex deposition in the kidneys drive disease progression. Current treatment strategies focus on supportive care, including blood pressure control and proteinuria reduction using renin-angiotensin system (RAS) blockers.   Newer therapeutic approaches are highlighted, such as targeted-release formulations like TRF-budesonide, which delivers corticosteroids to gut-associated lymphoid tissue to minimize systemic side effects.   Immunosuppressive treatments, including systemic corticosteroids, mycophenolate mofetil (MMF), and emerging therapies like complement inhibitors (e.g., Eculizumab, Ravulizumab), are explored for their efficacy and safety. B-cell and plasma cell-targeting therapies, complement inhibitors, and personalized medicine approaches represent emerging treatment avenues.   Combination therapies, such as corticosteroids with immunosuppressants, are also discussed, aiming to enhance treatment efficacy while minimizing adverse effects.   Personalized medicine and the integration of artificial intelligence for optimizing treatment strategies offer promising directions for improving outcomes in patients with IgAN. The review concludes by emphasizing the need for continued research to better understand IgAN's pathogenesis and further develop innovative therapies that prevent progression to end-stage kidney disease.

Objective With the rapid progression of urbanization and technological advancements, firefighters increasingly face complex emergency rescue challenges, making them more susceptible to Post-Traumatic Stress Disorder (PTSD). This study aims to develop an efficient tool to predict and identify PTSD risks among firefighters, ensuring their mental well-being and enhancing rescue efficiency. Methods Detailed data collection and analysis were conducted across multiple fire brigades. The data underwent a series of rigorous preprocessing steps, including cleaning, normalization, and feature importance screening. The SMOTE technique was employed to enhance sample balance. Subsequently, we constructed a predictive model based on the Stacking strategy, integrating multiple algorithms such as Random Forests, Gradient Boosting, Support Vector Machines, and k-Nearest Neighbors. Results The model consistently exhibited outstanding performance in a series of validation tests. Its overall accuracy reached an impressive 96%, with F1 scores of 0.94 and 0.98 for non-PTSD and PTSD categories, respectively. Conclusion We have successfully designed a highly precise PTSD risk prediction model for the fire safety domain. This not only aids in bolstering the psychological support for firefighters but also offers valuable insights for mental health research and public health policy formulation. This study hopes to provide value for both academic research and practical applications.

Background: This review examined factors contributing to gastrointestinal health behaviors using the COM-B (capability, opportunity, motivation) model. Methods: Five electronic databases (PubMed, Medline, Cochrane, Web of Science, CINAHL) were searched following PRISMA guidelines, extracting the data and applying the inductive deductive method to map the impact factors to the COM-B model. Results: The COM-B model identified 20 influencing factors mapped to five subcomponents: psychological capability, physical opportunity, social opportunity, reflective motivation, and automatic motivation. Conclusions: Enhancing gastrointestinal health entails considering personal, societal, and environmental considerations.

In contemporary China, the phenomenon of population ageing is becoming increasingly salient. The rapid growth of the elderly population has led to a concomitant rise in the prominence of the issue of elderly care, which is now a matter of growing public concern. The implementation of the community-based elderly care model plays a pivotal role in effectively responding to the challenges brought about by an ageing society. It can provide more comprehensive and caring elderly care services for the elderly, thereby further promoting the sustainable and sound development of the elderly care cause. Presently, deficiencies persist in the provision of community-based elderly care in China. These include insufficient service supply, imperfect facility construction and a shortage of human resources. To address these issues, it is imperative for the government and all societal sectors to collaborate, refine pertinent policies, facilitate the recruitment of advanced professionals, and implement other strategies. This will ensure that the elderly receive convenient, efficient, and accurate senior care services, allowing them to enjoy a peaceful twilight years.

Chronic diseases, also known as non communicable diseases (NCDs), refer to diseases that have a long course, slow progression, are difficult to cure, and typically require long-term medical care. Common chronic diseases include hypertension, diabetes and stroke. These diseases not only seriously affect the quality of life of patients, but also bring heavy economic burden to families and society. This article will focus on exploring the application and effectiveness of exercise therapy in chronic disease rehabilitation from the perspectives of prevention and rehabilitation.

Objective: To explore and analyze the therapeutic effects of physical factor therapy on chronic diseases. Method: A total of 104 patients with chronic diseases admitted to our hospital from July 2023 to July 2024 were selected as the research subjects. They were divided into a physical group (n=52) and a reference group (n=52) using a double-blind mechanism. The physics group received physical therapy, while the reference group received basic treatment. Compare the treatment efficacy, quality of life, and treatment satisfaction between two groups. Result: The total effective rate of the physics group was significantly higher than that of the reference group (P<0.05), and the difference was statistically significant. Before treatment, there was no statistically significant difference in the quality of life, including social integration, mental state, physiological function, and overall health, between the two groups (P>0.05); After treatment, the physical group showed significantly higher levels of social integration, mental state, physiological function, and overall health compared to the control group (P<0.05). The overall treatment satisfaction of the physics group was significantly higher than that of the reference group (P<0.05), and the difference was statistically significant. Conclusion: Physical factor therapy has significant therapeutic effects on chronic diseases and is worth promoting.

Objective: To establish a model of methicillin-resistant Staphylococcus aureus（MRSA） pneumonia and observe the effect of MRSA on macrophage polarization. Methods: The MRSA pneumonia model is established by adding 1×108CFU/mL MRSA bacterial solution to BALB/c mice through nasal drip. To make pathological specimens of lung tissue and observe the inflammation of the lungs;to detect the expression of F4/80, CD11B, CD206, and CD86 in mouse lung tissue through flow cytometry to reflect the polarization of macrophages and their M1/M2.

Result: Compared with the uninfected group, macrophages have increased significantly in infected group; The expression of CD206 in macrophages has significantly enhanced after infection, indicating the macrophage polarization towards M2;

Conclusion: MRSA pulmonary infection leads to a significant infiltration of macrophages in lung tissue and their polarization towards the M2 phenotype.