Eye Movement Desensitization and Reprocessing (EMDR) therapy has gained recognition as an effective intervention for Post-Traumatic Stress Disorder (PTSD), utilizing bilateral stimulation to process traumatic memories and reduce associated symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR compared to control conditions (e.g., waitlist, cognitive behavioral therapy) in targeting symptoms of PTSD, including intrusive thoughts, avoidance behaviors, hyperarousal, and negative cognitions. Additionally, it examines potential moderators of treatment outcomes, such as treatment protocol variations, therapist training, session length, and participant characteristics (e.g., type of trauma, comorbidities), to better understand the factors influencing the effectiveness of EMDR for PTSD.

Dialectical Behavior Therapy (DBT) has shown promise as an effective intervention for adolescents with Non-Suicidal Self-Injury (NSSI), providing skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing NSSI behaviors and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting frequency and severity of NSSI, suicidal ideation, emotion dysregulation, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, format (individual vs. group), therapist adherence, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of DBT for NSSI in adolescents.

Virtual Reality Exposure Therapy (VRET) has emerged as a promising intervention for Post-Traumatic Stress Disorder (PTSD), offering immersive and controlled environments for exposure to traumatic memories. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of VRET in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of VRET compared to control conditions (e.g., waitlist, traditional exposure therapy) in targeting symptoms of PTSD, including intrusive thoughts, avoidance behaviors, hyperarousal, and negative mood. Additionally, it examines potential moderators of treatment outcomes, such as the type of trauma, level of immersion, therapist involvement, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of VRET for PTSD.

Internet-Based Cognitive Behavioral Therapy (iCBT) has emerged as a convenient and accessible intervention for depression and anxiety, offering evidence-based treatment delivered through online platforms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of iCBT in reducing symptoms of depression and anxiety and improving overall mental health outcomes. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of iCBT compared to control conditions (e.g., waitlist, face-to-face therapy) in targeting depressive and anxiety symptoms, functional impairment, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as program duration, therapist guidance, interactivity of the platform, and participant characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of iCBT for depression and anxiety.

Schema Therapy (ST) has emerged as a promising intervention for Borderline Personality Disorder (BPD), targeting maladaptive schemas and core emotional needs. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ST in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ST compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting core symptoms of BPD, including emotional dysregulation, identity disturbance, interpersonal difficulties, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, mode of delivery (individual vs. group), therapist experience, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ST for BPD.

This article are supported by WELI Scientific.

 Mindfulness-Based Stress Reduction (MBSR) has gained popularity as an intervention to reduce stress and enhance well-being, particularly among healthcare professionals who face high levels of occupational stress. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing stress and improving overall well-being in healthcare professionals. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, active control interventions) in targeting stress levels, burnout, compassion fatigue, and job satisfaction. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, frequency of mindfulness practice, instructor qualifications, and participant characteristics (e.g., profession, years of experience), to better understand the factors influencing the effectiveness of MBSR for stress reduction in healthcare professionals.

Group therapy has long been recognized as a valuable intervention for individuals with substance use disorders, offering a supportive environment for peer interaction and shared experiences. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of group therapy in reducing substance use and improving overall functioning in individuals with substance use disorders. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of group therapy compared to control conditions (e.g., individual therapy, treatment as usual) in targeting substance use frequency, severity of dependence, cravings, and psychosocial functioning. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, group size, therapist involvement, and participant characteristics (e.g., substance of abuse, comorbidities), to better understand the factors influencing the effectiveness of group therapy for substance use disorders.

Acceptance and Commitment Therapy (ACT) has gained prominence as an effective intervention for anxiety disorders in adults, emphasizing acceptance of distressing thoughts and feelings and commitment to values-based action. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing anxiety symptoms and improving overall functioning in adults with anxiety disorders. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, active control interventions) in targeting core symptoms of anxiety, including generalized anxiety, social anxiety, panic attacks, and specific phobias. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session format (individual vs. group), therapist competence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for anxiety disorders in adults.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adolescents, offering comprehensive skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adolescents. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, interpersonal difficulties, impulsivity, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity of therapy, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD in adolescents.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adolescents, offering comprehensive skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adolescents. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, interpersonal difficulties, impulsivity, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity of therapy, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD in adolescents.

Cognitive Behavioral Therapy for Insomnia (CBT-I) has been established as the first-line treatment for chronic insomnia, offering effective strategies to improve sleep quality and quantity. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CBT-I in reducing insomnia severity and improving sleep-related outcomes in adults. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CBT-I compared to control conditions (e.g., waitlist, sleep hygiene education) in targeting sleep latency, wake after sleep onset, total sleep time, sleep efficiency, and subjective sleep quality. Additionally, it examines potential moderators of treatment outcomes, such as treatment components (e.g., sleep restriction, stimulus control), treatment format (individual vs. group), therapist involvement, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of CBT-I for insomnia in adults.

Mindfulness-Based Interventions (MBIs) have gained recognition as effective approaches for managing chronic pain, offering holistic strategies to alleviate suffering and improve quality of life. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBIs in reducing pain intensity and enhancing pain-related outcomes in individuals with chronic pain conditions. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBIs compared to control conditions (e.g., treatment as usual, active control interventions) in targeting pain severity, pain interference, physical functioning, and psychological distress. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session format (group vs. individual), mindfulness practice intensity, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of MBIs for chronic pain management.

 Family-Based Therapy (FBT), also known as Maudsley Approach, has emerged as a leading intervention for eating disorders in adolescents, focusing on empowering families to support their child's recovery. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of FBT in reducing eating disorder symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of FBT compared to control conditions (e.g., individual therapy, treatment as usual) in targeting core symptoms of eating disorders, including restrictive eating, binge eating, purging behaviors, and body image dissatisfaction. Additionally, it examines potential moderators of treatment outcomes, such as family involvement, therapist training, treatment duration, and participant characteristics (e.g., age, duration of illness), to better understand the factors influencing the effectiveness of FBT for eating disorders in adolescents.

Interpersonal Psychotherapy (IPT) has emerged as a promising intervention for depression in adolescents, focusing on improving interpersonal relationships and addressing psychosocial stressors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of depression, including low mood, anhedonia, irritability, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, session format (individual vs. group), therapist expertise, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of IPT for depression in adolescents.

Exposure Therapy (ET) has been recognized as a first-line treatment for Post-Traumatic Stress Disorder (PTSD) in military veterans, aiming to reduce symptoms of re-experiencing, avoidance, hyperarousal, and negative alterations in mood and cognition. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ET in reducing PTSD symptoms and improving overall functioning in military veterans. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ET compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of PTSD. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), length of exposure, therapist expertise, and participant characteristics (e.g., combat exposure, comorbidities), to better understand the factors influencing the effectiveness of ET for PTSD in military veterans.

Acceptance and Commitment Therapy (ACT) has emerged as a promising intervention for Major Depressive Disorder (MDD) in adults, focusing on fostering psychological flexibility and promoting valued living. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing depressive symptoms and improving overall functioning in adults with MDD. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of depression, including low mood, anhedonia, cognitive distortions, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session frequency, therapist competence, and participant characteristics (e.g., comorbidities, treatment history), to better understand the factors influencing the effectiveness of ACT for MDD in adults.

Cognitive Remediation Therapy (CRT) has emerged as a promising intervention for addressing cognitive deficits in individuals with schizophrenia, aiming to improve cognitive functioning and functional outcomes. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CRT in enhancing cognitive abilities and functional outcomes in individuals with schizophrenia. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CRT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting cognitive domains such as attention, memory, executive function, and social cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, session frequency, therapist involvement, and participant characteristics (e.g., duration of illness, symptom severity), to better understand the factors influencing the effectiveness of CRT for schizophrenia.

Mindfulness-Based Stress Reduction (MBSR) has gained attention as a potential intervention for Generalized Anxiety Disorder (GAD) in adults, offering a holistic approach to reducing anxiety symptoms and improving overall well-being. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing anxiety symptoms and enhancing psychological functioning in adults with GAD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of GAD, including excessive worry, somatic symptoms, and cognitive distortions. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session frequency, participant adherence, and baseline characteristics (e.g., severity of anxiety, comorbidities), to better understand the factors influencing the effectiveness of MBSR for GAD in adults.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adults, offering a comprehensive approach to addressing the core symptoms and functional impairments associated with the disorder. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adults. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, impulsivity, interpersonal difficulties, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence, participant characteristics (e.g., comorbidities, severity of symptoms), and session format (individual vs. group), to better understand the factors influencing the effectiveness of DBT for BPD in adults.

Parent-Child Interaction Therapy (PCIT) has emerged as a leading intervention for young children with disruptive behavior disorders, providing a structured and empirically supported approach to improving parent-child interactions and reducing problem behaviors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PCIT in reducing disruptive behavior symptoms and improving parent-child relationships in young children. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PCIT compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of disruptive behavior disorders, including oppositional behavior, aggression, defiance, and noncompliance. Additionally, it examines potential moderators of treatment outcomes, such as therapist fidelity, parent involvement, session format (individual vs. group), and child characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of PCIT for young children with disruptive behavior disorders.