Background: Observational studies have demonstrated a relationship between leukocyte telomere length (LTL) and psoriasis. However, the causal association between them remains unknown.

Methods: Bidirectional Mendelian randomization (MR) analysis was performed using publicly available genome-wide association study (GWAS) summary statistics. The GWAS summary data involving 472,174 participants for ITL were obtained from the UKbiobank, while the summary data for psoriasis (8,075 cases) and its two main types, psoriasis vulgaris (PsV, 5,018 cases) and psoriatic arthritis (PsA, 2,919 cases) were obtained from the FinnGen consortium. The inverse variance weighted (IVW) method was used as the main analysis.

Results: The forward MR analyses indicated that genetically determined LTL was suggestively associated with psoriasis (IVW: OR: 0.858; 95% CI: 0.752-0.980; P= 0.024) and significantly associated with PsV (IVW: OR: 0.790; 95% CI: 0.671-0.931; P= 0.005), but not with PsA (IVW: OR: 0.845; 95% CI: 0.685-1.043; p= 0.117). The reverse MR analyses showed that no causal effects were observed in psoriasis and its two subtypes on LTL.

Conclusion: Our study suggested a potential causal effect of shortened LTL on the increased risk of psoriasis, especially PsV, providing LTL as a novel biomarker and therapeutic target for psoriasis.

Current monitoring systems employing single model algorithms face challenges in accurately recognizing and alerting real-time arrhythmic events in patients with severe cardiac conditions. To address this issue and improve the detection accuracy of electrocardiogram (ECG) monitoring systems, this paper introduces a novel arrhythmia recognition model based on Stacking ensemble learning. This model integrates multiple base learners, including LightGBM, XGBoost, Random Forest, SVM, and Logistic Regression, and optimizes them using Gradient Boosting as the meta-learner. Hyperparameters were fine-tuned through grid search, and nested cross-validation was employed to train the model, ensuring robust predictive performance. The detection results indicate that the Stacking ensemble model significantly outperforms single models in both accuracy and stability, offering substantial practical application value for clinical ECG monitoring and diagnosis.

Background: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are biomarkers for the diagnosis and prognosis of many diseases. However, the diagnostic accuracy of IVIG resistant Kawasaki disease is still unclear. This study aims to evaluate the diagnostic value of NLR and PLR in IVIG resistant Kawasaki disease. Method: We used Pubmed, Embase, Web of science, CNKI and Google academic database to find all articles that met the inclusion criteria until January 5 2024.Result: After two independent researchers carefully read the title, abstract, and full text, five eligible studies were included in the study analysis, with a total of 3359 children included. The research results showed that the combined sensitivity and specificity were 0.57 (95% CI: 0.48-0.66) and 0.73 (95% CI: 0.67-0.78), respectively; The pooled positive likelihood ratio and Negative likelihood ratio were2.12（95%CI:1.91-2.34）and 0.58（95%CI:0.50-0.68）, respectively;The pooled DOR was 3.62（95% CI:2.99-4.39）;The area under the SROC curve (AUC) was 0.71 (95% CI: 0.67-0.75), indicating high diagnostic performance. Conclusion: This study analysis indicates that the PLR+NLR levels in children with Kawasaki disease can serve as an important parameter in the risk scoring system, with relatively high accuracy.

Papillary thyroid carcinoma (PCT), follicular origin are divided into RAS-like malignancies and BRAF-like malignancies according to their molecular characteristics and aggressiveness. With the continuous development of the molecular level, genetic mutations are significant in the diagnosis, treatment and prognosis of papillary thyroid carcinoma. This paper discusses the latest progress of papillary thyroid cancer gene mutation and its clinical application, in order to provide more efficient diagnosis and treatment means for patients.

Mindfulness-Based Stress Reduction (MBSR) has emerged as a promising intervention for chronic pain management, emphasizing mindfulness meditation and body awareness to cultivate acceptance and reduce pain-related distress. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing pain intensity and improving pain-related outcomes in individuals with chronic pain conditions, such as fibromyalgia, low back pain, and arthritis. Through a thorough literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual, active interventions) in targeting pain intensity, pain interference, physical functioning, and psychological distress. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, frequency of mindfulness practice, therapist experience, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of MBSR for chronic pain.

Acceptance and Commitment Therapy (ACT) has gained recognition as a transdiagnostic approach for treating anxiety disorders, emphasizing acceptance of internal experiences and commitment to value-based actions to foster psychological flexibility. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing anxiety symptoms and improving overall functioning in individuals with various anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), and specific phobias. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual, active interventions) in targeting anxiety symptoms, including worry, fear, avoidance behaviors, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence to ACT principles, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for anxiety disorders.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD), integrating cognitive-behavioral techniques with mindfulness and acceptance-based strategies to address emotion dysregulation, impulsivity, and interpersonal difficulties. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through an exhaustive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, supportive therapy, waitlist) in targeting BPD symptoms, including affective instability, self-harm behaviors, and interpersonal problems. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence to DBT principles, treatment setting (inpatient vs. outpatient), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD.

Cognitive Behavioral Therapy (CBT) has been established as a first-line treatment for Generalized Anxiety Disorder (GAD), targeting maladaptive cognitive patterns and excessive worry through cognitive restructuring and exposure-based techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CBT in reducing GAD symptoms and improving overall functioning in individuals with GAD. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CBT compared to control conditions (e.g., waitlist, supportive therapy, relaxation training) in targeting GAD symptoms, including worry, physiological arousal, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of CBT for GAD.

Interpersonal Psychotherapy (IPT) has emerged as a structured and time-limited psychotherapeutic approach for treating Major Depressive Disorder (MDD), focusing on improving interpersonal functioning and resolving interpersonal problems that contribute to depressive symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving overall functioning in individuals with MDD. Through an exhaustive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, cognitive-behavioral therapy, supportive therapy) in targeting depressive symptoms, including mood disturbance, interpersonal difficulties, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of IPT for MDD.

Eye Movement Desensitization and Reprocessing (EMDR) has gained recognition as a psychotherapeutic approach for treating Posttraumatic Stress Disorder (PTSD), involving bilateral stimulation while processing traumatic memories to alleviate distress and promote adaptive resolution. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR compared to control conditions (e.g., waitlist, cognitive-behavioral therapy, supportive therapy) in targeting PTSD symptoms, including re-experiencing, avoidance, hyperarousal, and negative cognitions. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., trauma type, comorbidities), to better understand the factors influencing the effectiveness of EMDR for PTSD.

Motivational Interviewing (MI) has gained prominence as a patient-centered approach to addressing substance use disorders (SUDs), aiming to enhance intrinsic motivation for behavior change by exploring and resolving ambivalence. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MI in reducing substance use and improving treatment outcomes in individuals with SUDs. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MI compared to control conditions (e.g., treatment as usual, psychoeducation, brief advice) in targeting substance use outcomes, including frequency, quantity, and severity of substance use, as well as treatment retention and engagement. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence to MI principles, patient readiness to change, and substance type, to better understand the factors influencing the effectiveness of MI for SUDs.

Mindfulness-Based Stress Reduction (MBSR) has emerged as a popular intervention for chronic pain management, incorporating mindfulness meditation, yoga, and body awareness practices to cultivate nonjudgmental awareness and acceptance of pain sensations. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing pain intensity and improving pain-related outcomes in individuals with chronic pain conditions. Through an exhaustive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual, active control) in targeting pain intensity, pain interference, physical functioning, and psychological well-being. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, adherence to practice, therapist involvement, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of MBSR for chronic pain management.

Acceptance and Commitment Therapy (ACT) has gained recognition as a promising intervention for Generalized Anxiety Disorder (GAD), emphasizing acceptance of distressing thoughts and feelings while promoting committed action toward values-based goals. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing GAD symptoms and improving overall functioning in individuals with GAD. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual, active control) in targeting GAD symptoms, including worry, somatic symptoms, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for GAD.

Dialectical Behavior Therapy (DBT) has become one of the leading treatments for Borderline Personality Disorder (BPD), focusing on enhancing emotion regulation skills, interpersonal effectiveness, distress tolerance, and mindfulness. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, supportive therapy, active control) in targeting BPD symptoms, including impulsivity, affective instability, identity disturbance, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD.

Cognitive Processing Therapy (CPT) has emerged as a widely used and evidence-based treatment for Posttraumatic Stress Disorder (PTSD) in military veterans, focusing on cognitive restructuring techniques to address trauma-related beliefs and symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CPT in reducing PTSD symptoms and improving overall functioning in military veterans with PTSD. Through an exhaustive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CPT compared to control conditions (e.g., waitlist, treatment as usual, supportive therapy) in targeting PTSD symptoms, including re-experiencing, avoidance, hyperarousal, and negative cognitions. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., combat exposure, comorbidities), to better understand the factors influencing the effectiveness of CPT for PTSD in military veterans.

Exposure and Response Prevention (ERP) is considered the gold standard psychotherapy for Obsessive-Compulsive Disorder (OCD), focusing on exposing individuals to feared stimuli while preventing ritualistic responses to reduce symptom severity and improve functioning. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ERP in reducing OCD symptoms and improving quality of life in individuals with OCD. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ERP compared to control conditions (e.g., waitlist, supportive therapy, medication only) in targeting OCD symptoms, including obsessions, compulsions, and associated impairment. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist involvement, treatment format (individual vs. group), and participant characteristics (e.g., age, symptom severity), to better understand the factors influencing the effectiveness of ERP for OCD.

Parent-Child Interaction Therapy (PCIT) has emerged as a leading intervention for disruptive behavior disorders in children, aiming to improve parent-child interactions and reduce problem behaviors through structured coaching and behavioral techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PCIT in reducing disruptive behavior symptoms and improving parent-child relationships in children with disruptive behavior disorders. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PCIT compared to control conditions (e.g., waitlist, treatment as usual, parent education) in targeting disruptive behavior symptoms, including aggression, defiance, and conduct problems. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist involvement, treatment fidelity, and child characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of PCIT for disruptive behavior disorders in children.

Mindfulness-Based Cognitive Therapy (MBCT) has emerged as a promising intervention for preventing relapse and recurrence of depression, combining cognitive therapy techniques with mindfulness practices to target cognitive reactivity and promote self-regulation skills. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBCT in reducing depressive relapse/recurrence and improving overall well-being in individuals with a history of recurrent depression. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBCT compared to control conditions (e.g., treatment as usual, maintenance antidepressant medication, placebo) in preventing depressive relapse/recurrence and reducing residual depressive symptoms. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, frequency of sessions, therapist involvement, and participant characteristics (e.g., history of depression, comorbidities), to better understand the factors influencing the effectiveness of MBCT for recurrent depression.

Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) has emerged as a leading intervention for childhood trauma, aiming to address trauma-related symptoms and improve coping strategies in children and adolescents. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of TF-CBT in reducing trauma-related symptoms and improving overall functioning in youth with a history of trauma exposure. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of TF-CBT compared to control conditions (e.g., waitlist, treatment as usual, supportive therapy) in targeting trauma symptoms, including post-traumatic stress symptoms, depression, anxiety, and behavioral problems. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, type of trauma), to better understand the factors influencing the effectiveness of TF-CBT for childhood trauma.

Acceptance and Commitment Therapy (ACT) has gained recognition as a promising intervention for chronic pain management, focusing on promoting psychological flexibility and enhancing patients' ability to pursue meaningful life activities despite pain. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing pain intensity and improving pain-related disability in individuals with chronic pain conditions. Through an exhaustive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., treatment as usual, waitlist, other psychotherapies) in targeting pain outcomes, including pain intensity, pain interference, and psychological distress. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and patient characteristics (e.g., pain duration, pain etiology), to better understand the factors influencing the effectiveness of ACT for chronic pain management.