Input keywords, title, abstract, author, affiliation etc..
Journal Article An open access journal
Journal Article

Analysis of the correlation between c-reactive protein levels and ferritin in patients with chronic heart failure

by Jiahao Song 1 JiaQi Sun 1  and  Zhimin Fang 1,*
1
The Second Affiliated Hospital of Xinjiang Medical University
*
Author to whom correspondence should be addressed.
Received: / Accepted: / Published Online: 21 April 2025

Abstract

Objective: This study was to investigate the correlation between serum CRP levels and ferritin in patients with chronic heart failure.

Methods: This study is a cross-sectional study. We investigated 210 patients with heart failure who attended the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Xinjiang Medical University from December 2023 to February 2025. Comparison of iron parameters between different ultrasensitive C-reactive protein quartiles was made.

Results: The highest quartile group (Q4) of ultrasensitive C-reactive protein had significantly higher serum ferritin levels than the first (Q1) second (Q2) and third (Q3) quartile groups, Q1 [133.7 (88.4, 204.8)],Q2 [129.0 (77.1, 256.8)],Q3 [121.3 (58.7, 189.5)],Q4 [202.0 ( 106.3446.2)], p < 0.05.

Conclusion: Ferritin levels in patients with chronic heart failure are influenced by a number of factors in their condition, and the use of ferritin may overestimate the iron status of patients with chronic heart failure.


Copyright: © 2025 by Song, Sun and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Share and Cite

ACS Style
Song, J.; Sun, J.; Fang, Z. Analysis of the correlation between c-reactive protein levels and ferritin in patients with chronic heart failure. Journal of Public Health & Environment, 2025, 8, 266. doi:10.69610/j.phe.20250421
AMA Style
Song J, Sun J, Fang Z. Analysis of the correlation between c-reactive protein levels and ferritin in patients with chronic heart failure. Journal of Public Health & Environment; 2025, 8(2):266. doi:10.69610/j.phe.20250421
Chicago/Turabian Style
Song, Jiahao; Sun, JiaQi; Fang, Zhimin 2025. "Analysis of the correlation between c-reactive protein levels and ferritin in patients with chronic heart failure" Journal of Public Health & Environment 8, no.2:266. doi:10.69610/j.phe.20250421

Article Metrics

Article Access Statistics

References

  1. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail (2022) 24:4–131. doi: 10.1002/ejhf.2333
  2. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. Journal of the American College of Cardiology (2022) 79:e263–e421. doi: 10.1016/j.jacc.2021.12.012
  3. Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovascular Research (2023) 118:3272–3287. doi: 10.1093/cvr/cvac013
  4. Tkaczyszyn M, Comín-Colet J, Voors AA, van Veldhuisen DJ, Enjuanes C, Moliner-Borja P, Rozentryt P, Poloński L, Banasiak W, Ponikowski P, et al. Iron deficiency and red cell indices in patients with heart failure. Eur J Heart Fail (2018) 20:114–122. doi: 10.1002/ejhf.820
  5. Alcaide-Aldeano A, Garay A, Alcoberro L, Jiménez-Marrero S, Yun S, Tajes M, García-Romero E, Díez-López C, González-Costello J, Mateus-Porta G, et al. Iron deficiency: Impact on functional capacity and quality of life in heart failure with preserved ejection fraction. J Clin Med (2020) 9: doi: 10.3390/jcm9041199
  6. Corrigendum to: Iron deficiency and risk of early readmission following a hospitalization for acute heart failure: Iron deficiency and rehospitalization (European Journal of Heart Failure, (2016), 18, 7, (798-802), 10.1002/ejhf.513). Eur J Heart Fail (2022) 24:591. doi: 10.1002/ejhf.2396
  7. Abu-Own H, Webb I, Okonko DO. Intravenous iron repletion in heart failure: bridging the gap between symptom relief and hard clinical outcomes. Eur Heart J (2023) 44:5092–5094. doi: 10.1093/eurheartj/ehad746
  8. Baral N, Karki NR, Rauniyar R, Savarapu P, Abdelazeem B, Khan A, Christy J, Kandah E, Adhikari G, Dhungana S, et al. Intravenous iron decreases rehospitalizations but doesn’t change mortality in patients admitted with acute heart failure and iron deficiency: A systematic review and meta-analysis. Circulation (2021) 144: doi: 10.1161/circ.144.suppl_1.12675
  9. Adlbrecht C. Intravenous iron therapy for patients with heart failure: expanding body of evidence. ESC Heart Fail (2019) 6:581–583. doi: 10.1002/ehf2.12490
  10. Aggarwal A, Premkumar M, Mallik N, Zohmangaihi D, Lad D, Divyaveer S, Singh V, Kaur H, Kaur H, Kekan K, et al. Assessment of role of iron metabolism, vitamin deficiency, gastrointestinal blood loss, and chronic inflammation in the etiopathogenesis of anemia in chronic liver disease. Am J Gastroenterol (2021) 116:S1398–S1399. doi: 10.14309/01.ajg.0000787144.62681.ed
  11. Braga F, Panteghini M. Biologic variability of C-reactive protein: is the available information reliable? Clin Chim Acta (2012) 413:1179–1183. doi: 10.1016/j.cca.2012.04.010
  12. Ton V-K, Drezek K, Boerboom S, Ostrom KF, Birchenough C, Camuso J, Logan T, Milley K, Anthony A, Thomas SS, et al. Persistent Iron Deficiency and Dysregulated Hepcidin Levels After Durable Left Ventricular Assist Device Therapy. ASAIO J (2023) 69:e152–e154. doi: 10.1097/MAT.0000000000001811
  13. Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun (2018) 70:61–75. doi: 10.1016/j.bbi.2018.02.013
  14. Awad AK, Abdelgalil MS, Gonnah AR, Mouffokes A, Ahmad U, Awad AK, Elbadawy MA, Roberts DH. Intravenous iron for acute and chronic heart failure with reduced ejection fraction (HFrEF) patients with iron deficiency: An updated systematic review and meta-analysis. Clin Med (Lond) (2024) 24:100211. doi: 10.1016/j.clinme.2024.100211
  15. Cleland J, Kalra P, Pellicori P, Graham F, Foley P, Squire I, Cowburn P, Seed A, Clark A, Szwejkowski B, et al. Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European heart journal (2024) 45:1410‐1426. doi: 10.1093/eurheartj/ehae086
  16. Drozd MD, Tkaczyszyn M, Kasztura M, Węgrzynowska-Teodorczyk K, Flinta I, Banasiak W, Ponikowski P, Jankowska EA. Intravenous iron supplementation improves energy metabolism of exercising skeletal muscles without effect on either oxidative stress or inflammation in male patients with heart failure with reduced ejection fraction. Cardiol J (2024) 31:300–308. doi: 10.5603/cj.97253
  17. Ambrosy A, von Haehling S, Kalra P, Court E, Bhandari S, McDonagh T, Cleland J. Safety and Efficacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deficiency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure. American journal of cardiology (2021) 152:138‐145. doi: 10.1016/j.amjcard.2021.04.042
  18. Yamani N, Ahmed A, Gosain P, Fatima K, Shaikh AT, Qamar H, Shahid I, Arshad MS, Almas T, Figueredo V. Effect of iron supplementation in patients with heart failure and iron deficiency: A systematic review and meta-analysis. Int J Cardiol Heart Vasc (2021) 36:100871. doi: 10.1016/j.ijcha.2021.100871
  19. Docherty KF. SGLT2 Inhibitors and Iron: More Than Meets the Eye. JACC Heart Fail (2023) 11:1623–1625. doi: 10.1016/j.jchf.2023.08.013