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Volume 8, 2025 - Issue 2

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Analysis of potential mechanisms of improvement of abnormal uterine bleeding by Erzhi Pill based on network pharmacology and molecular docking technique

by Xiao Han 1 ,  Pengyu Han 1 ,  Yixin Li 3  and  Xiaomao Liu 2,*
1
The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
2
Department of Gynecology, Yulin Hospital of Traditional Chinese Medicine, Yulin, Shaanxi, China
3
Xi'an Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, China
*
Author to whom correspondence should be addressed.
JPHE  2025 8(2):261; https://doi.org/10.69610/j.phe.2025030102
Received: / Accepted: / Published Online: 1 March 2025
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Abstract

OBJECTIVE: This study aimed to uncover potential targets and mechanisms for the treatment of abnormal uterine bleeding through a network pharmacological study of Erzhi Pills

METHODS: Network pharmacology was used to predict the active ingredients and potential targets for abnormal uterine bleeding of Erzhi Pill, and the binding affinity was explored using molecular docking techniques. The relevant associated signalling pathways were studied using GO and KEGG enrichment analysis.

RESULTS: Based on the network pharmacology results, two key active ingredients, Acetin and Kaempferol, were screened, and three potential therapeutic targets, TP53, TNF, and AKT1, were screened using STRING and PPI networks. The enrichment analysis showed that these potential therapeutic targets were mainly involved in signalling pathways related to metabolism and inflammation. The binding was observed using the molecular docking technique, and both active ingredients and potential targets showed good affinity.

CONCLUSION: This study contributes new research evidence on the potential mechanism of Erzhi Pill in the treatment of abnormal uterine bleeding. The results of both network pharmacology and molecular docking techniques suggest a potential therapeutic effect of Erzhi Pill on abnormal uterine bleeding. However, these results need to be further investigated to provide more profound clinical information.

Keywords: Erzhi Pills; abnormal uterine bleeding; network pharmacology; molecular docking.;
Copyright: © 2025 by Han, Han, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Han, X.; Han, P.; Li, Y.; Liu, X. Analysis of potential mechanisms of improvement of abnormal uterine bleeding by Erzhi Pill based on network pharmacology and molecular docking technique. Journal of Public Health & Environment, 2025, 8, 261. doi:10.69610/j.phe.2025030102
AMA Style
Han X, Han P, Li Y et al.. Analysis of potential mechanisms of improvement of abnormal uterine bleeding by Erzhi Pill based on network pharmacology and molecular docking technique. Journal of Public Health & Environment; 2025, 8(2):261. doi:10.69610/j.phe.2025030102
Chicago/Turabian Style
Han, Xiao; Han, Pengyu; Li, Yixin; Liu, Xiaomao 2025. "Analysis of potential mechanisms of improvement of abnormal uterine bleeding by Erzhi Pill based on network pharmacology and molecular docking technique" Journal of Public Health & Environment 8, no.2:261. doi:10.69610/j.phe.2025030102

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