Login / Register Submit Your Article
cover
Journal of Public Health & Environment

Volume 8, 2025 - Issue 2

Submit Manuscript Journal Homepage
Latest Issue
Input keywords, title, abstract, author, affiliation etc..
Article Menu
Browse this journal
Vol. 8 (2025)
Vol. 7 (2024)
Vol. 6 (2023)
Vol. 5 (2022)
Vol. 4 (2021)
Vol. 3 (2020)
Vol. 2 (2019)
Vol. 1 (2018)
Updates more >>
1 February 2024 Journal of Public Health & Environment Honors Exceptional Reviewers with 2023 Best Reviewer Awards
1 June 2023 Statement on Supporting the Use of GPT Models in Research
1 March 2023 Journal of Public Health & Environment Honors Distinguished Reviewer of 2022
31 January 2022 Best Reviewer Award for 2021
5 February 2020 Call for Papers: Special Issue 2020
Cooperative Partner

 

  

Journal Article An open access journal
Journal Article

Based on the Theory of "Mutual Nourishment of Spleen and Kidney" to Discuss the Spleen and Kidney-TianGui-ChongRen-Uterus Menstrual Axis

by Xiaoju Shui 1,2 ,  Bo Wei 1,2  and  Shimei Li 2,*
1
Shaanxi University of Chinese Medicine, Xianyang, Shaanxi
2
Department of Traditional Chinese Medicine, Air Force 986 Hospital, Xi'an, Shaanxi
*
Author to whom correspondence should be addressed.
JPHE  2025 8(2):260; https://doi.org/10.69610/j.phe.2025030101
Received: / Accepted: / Published Online: 1 March 2025
View Full-Text
Download PDF

Abstract

Based on the theory of "mutual nourishment between the spleen and kidney," this paper explores the regulatory mechanisms of the spleen and kidney in the menstrual axis under Traditional Chinese Medicine (TCM) theory. It systematically discusses the core role of the Spleen and Kidney-Tian Gui-Chong Ren-Uterus axis in the physiology and pathology of female menstruation. By reviewing classical TCM literature and modern research findings, the paper argues for the synergistic regulation of the spleen and kidney on the production of Tian Gui(Gate of Life), the controlling and replenishment of Thoroughfare-Conception Vessels, and the storage and discharge functions of the uterus. Combining modern research on the neuro-endocrine reproductive axis, the paper elucidates the functional connections between the spleen-kidney theory and the hypothalamic-pituitary-ovarian (HPO) axis. It also summarizes the experiences of ancient and modern physicians in treating menstrual disorders from the perspective of the spleen and kidney, aiming to provide new insights for the exploration and application of the female menstrual axis in modern TCM and to offer references for the clinical diagnosis and treatment of menstrual disorders.

Keywords: Traditional Chinese Gynecology; Mutual Nourishment of Spleen and Kidney; Hypothalamus-Pituitary-Ovarian Axis (HPO); Spleen and Kidney-TianGui-ChongRen-Uterus Menstrual Axis; Menstrual Disorders.;
Copyright: © 2025 by Shui, Wei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Share and Cite

ACS Style
Shui, X.; Wei, B.; Li, S. Based on the Theory of "Mutual Nourishment of Spleen and Kidney" to Discuss the Spleen and Kidney-TianGui-ChongRen-Uterus Menstrual Axis. Journal of Public Health & Environment, 2025, 8, 260. doi:10.69610/j.phe.2025030101
AMA Style
Shui X, Wei B, Li S. Based on the Theory of "Mutual Nourishment of Spleen and Kidney" to Discuss the Spleen and Kidney-TianGui-ChongRen-Uterus Menstrual Axis. Journal of Public Health & Environment; 2025, 8(2):260. doi:10.69610/j.phe.2025030101
Chicago/Turabian Style
Shui, Xiaoju; Wei, Bo; Li, Shimei 2025. "Based on the Theory of "Mutual Nourishment of Spleen and Kidney" to Discuss the Spleen and Kidney-TianGui-ChongRen-Uterus Menstrual Axis" Journal of Public Health & Environment 8, no.2:260. doi:10.69610/j.phe.2025030101

Article Metrics

Article Access Statistics

References

  1. Huang Di Nei Jing·Su Wen [M]. Tian Daihua,clear up. Beijing: People's Medical Publishing House, 2017.
  2. Luo Yuankai. The Application of Regulating Kidney Yin and Kidney Yang in Gynecological Diseases [J]. New Chinese Medicine, 1974, 6(1):8.
  3. Luo Yuankai. Luo Yuankai's Medical Collection [M]. Beijing: People's Medical Publishing House, 1990.
  4. Yang Jialin. The Key Link in Menstrual Production - The Kidney-Tian Gui-Chong Ren-Uterus Axis [J]. Sichuan Chinese Medicine, 1983, 1(2):14-16.
  5. Zhang Yuzhen. Chinese Gynecology [M]. Beijing: China Press of Traditional Chinese Medicine, 2002:19.
  6. Xia Guicheng. Xia Guicheng's Practical Chinese Gynecology [M]. Beijing: China Press of Traditional Chinese Medicine, 2009:4-6.
  7. Peng Cheng, Liu Fangyuan, Shen Ying, et al. A Glimpse into the Theory of "Mutual Reinforcement between the Spleen and Kidney" in the Treatment of Gynecological Tumors [J]. Liaoning Journal of Traditional Chinese Medicine, 2022, 49(08):45-48. DOI:10.13192/j.issn.1000-1719.2022.08.013.
  8. Sun Haixia. The Theoretical Origin of "Mutual Reinforcement between the Spleen and Kidney" and Its Influence on Later Generations [J]. Journal of Shanxi College of Traditional Chinese Medicine, 2007, 8(3):14-15.
  9. Li Dongyuan. Pi Wei Lun [M]. Wen Kui, Ding Guohua,clear up. Beijing: People's Medical Publishing House, 1957:4,37.
  10. Tian Sisheng. Zhu Danxi's Complete Medical Works [M]. Beijing: China Press of Traditional Chinese Medicine, 2006:140.
  11. Sun Haixia. The Theoretical Origin of "Mutual Reinforcement between the Spleen and Kidney" and Its Influence on Later Generations [J]. Journal of Shanxi College of Traditional Chinese Medicine, 2007, (03):14-15.
  12. Zeng Qian. Professor Yang Jialin's Experience in Treating Gynecological Diseases from the Perspective of the Liver and Kidney [J]. Chinese Journal of Emergency Medicine, 2005, 14(6):552-553.
  13. Tan Zhongle, Lei Lei. Discussion on the Treatment of Leukorrhea from the Perspective of the Spleen, Liver, and Kidney in Fu Qing Zhu Nu Ke [J]. Journal of Changchun University of Chinese Medicine, 2010, 26(5):797.
  14. Huang Yuanyu. Huang Yuanyu's Medical Essence·Si Sheng Xin Yuan [M]. Beijing: China Press of Traditional Chinese Medicine, 2014.
  15. Based on the "Pivot Movement" to Analyze the "Spleen-Liver-Chong Ren-Uterus Menstrual Axis" Xu Yun, Wang Suli, Li Shimei 0253-9802.2022.12.005.
  16. Zhang Yu. A Brief Discussion on the Relationship between Kidney Governing Reproduction and Female Reproductive Endocrinology [J]. Gansu Journal of Traditional Chinese Medicine, 2002, (03):59-60.
  17. Zhang Cuimei. A Study on the Distribution of TCM Syndromes and the Correlation with Sex Hormones in Patients with Ovulatory Dysfunction Infertility [D]. Fujian University of Traditional Chinese Medicine, 2011.
  18. Li Weihong, Li Wenjie, Xue Yan. A Study on the Correlation between TCM Syndromes and Serum Hormone Levels in Patients with Dysfunctional Uterine Bleeding [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2016, 36(09):1061-1064.
  19. Ding Weijun, Gao Feng, Yang Jie, et al. A Clinical Study on the Imbalance of Intestinal Flora in Patients with Kidney Yang Deficiency Syndrome [J]. New Chinese Medicine, 2007(1):9-10.
  20. RIVIR A, SELAK M, LANTIN D, et al. Bifido Bacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut [J]. Front Microbiol, 2016, 7:797.
  21. Dong Kaizhong, Gao Yongsheng, Qin Ning'enjia, et al. The Effect of Shen Ling Bai Zhu San on Mice with Intestinal Flora Imbalance Caused by Antibiotics [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2015, 21(1):154-157.
  22. Sv LYNCH, O PEDERSEN. The Human Intestinal Microbiome in Health and Disease [J]. New Engl J Med, 2016, 375(24):2369-2379.
  23. Zhong Jiawen, Jiang Bo, Zhang Wenyan, et al. Liu Wei Di Huang Wan Regulates Intestinal Microbiome Balance to Inhibit Oxidative Stress in Ovarian Failure Mice [J]. Chinese Journal of Tissue Engineering Research, 2025, 29(11):2285-2293.
  24. Zhang Aomen. Clinical Observation of Shen Zhu Tiao Pi Granules in Treating Lean Type 2 Diabetes with Spleen Qi Deficiency Syndrome [D]. Anhui University of Chinese Medicine, 2024. DOI:10.26922/d.cnki.ganzc.2024.000330.
  25. Xu Huimin, Sun Kefeng, Li Chuling. Research Progress on TCM Regulation of Endoplasmic Reticulum Stress in the Treatment of Polycystic Ovary Syndrome [J/OL]. Journal of Liaoning University of Traditional Chinese Medicine, 1-15[2025-02-27].
  26. Cai Lirong, Li Dajin, Sun Xiaoxi, et al. A Study on the Preventive and Therapeutic Effects of Bu Shen Huo Xue Fang on Experimental Ovarian Failure in Mice [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2001, 21(2):126-129.
  27. Dong Ruoxi, Zhu Xiaodan, Fan Bozhen, et al. The Effect of Icariin on Ovarian Reserve Function in Cisplatin-Induced Ovarian Failure Rats [J]. Zhejiang Medical Journal, 2019, 41(3):230-233.
  28. Huang Changsheng, He Shoudi, Guan Yancheng, et al. The Effect of Cuscuta Flavonoids and Quercetin on Ovarian Function in Tripterygium Glycosides-Induced Ovarian Failure Rats [J]. Chinese Journal of Clinical Pharmacology, 2020, 36(6):667-670.
  29. Zhang Yujie, Wang Yingxin, Zhang Ning. Exploration of Qi Gong Wan Fang Regulating Granulosa Cell Autophagy in PCOS Phlegm-Dampness Syndrome Model Rats Based on the AMH/AMHRⅡ Pathway [J]. Lishizhen Medicine and Materia Medica Research, 2024, 35(15):3370-3376.
  30. Nan Nan, Du Xiaoli. The Academic Thought of Treating Gynecological Diseases from the Perspective of the Spleen and Stomach in Fu Qing Zhu Nu Ke [J]. Hebei Journal of Traditional Chinese Medicine, 2024, 46(01):142-145.
  31. Long Bingxi. On Zhang Jingyue's Emphasis on the Spleen and Kidney [J]. Hubei Journal of Traditional Chinese Medicine, 2003, (03):3-4.
  32. Zhao Ruihua. The Application of Lu Zhizheng's Spleen and Stomach Theory in Gynecology Clinical Practice [J]. Journal of Traditional Chinese Medicine, 2021, 62(16):1455-14.
  33. Peng Cheng, Liu Fangyuan, Shen Ying, et al. A Glimpse into the Theory of "Mutual Reinforcement between the Spleen and Kidney" in the Treatment of Gynecological Tumors [J]. Liaoning Journal of Traditional Chinese Medicine, 2022, 49(08):45-48. DOI:10.13192/j.issn.1000-1719.2022.08.013.
  34. Liu Wen'e, Tan Zhenyu, Chen Yanxia, et al. You Zhaoling's "Warming the Ovaries to Nourish the Follicles" Treatment Approach and Application [J]. Journal of Traditional Chinese Medicine, 2014, 55(20):1726-1728. DOI:10.13288/j.11-2166/r.2014.20.005.