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Causal Association Between Leukocyte Telomere Length and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study

by Haitao Zhuo 1,*
1
Affiliated Qingyuan Hospital,Guangzhou Medical University,Qingyuan People's Hospital
*
Author to whom correspondence should be addressed.
JPHE  2024 7(1):245; https://doi.org/10.69610/j.phe.20240709
Received: 9 May 2024 / Accepted: 3 July 2024 / Published Online: 9 July 2024
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Abstract

Background: Observational studies have demonstrated a relationship between leukocyte telomere length (LTL) and psoriasis. However, the causal association between them remains unknown.

Methods: Bidirectional Mendelian randomization (MR) analysis was performed using publicly available genome-wide association study (GWAS) summary statistics. The GWAS summary data involving 472,174 participants for ITL were obtained from the UKbiobank, while the summary data for psoriasis (8,075 cases) and its two main types, psoriasis vulgaris (PsV, 5,018 cases) and psoriatic arthritis (PsA, 2,919 cases) were obtained from the FinnGen consortium. The inverse variance weighted (IVW) method was used as the main analysis.

Results: The forward MR analyses indicated that genetically determined LTL was suggestively associated with psoriasis (IVW: OR: 0.858; 95% CI: 0.752-0.980; P= 0.024) and significantly associated with PsV (IVW: OR: 0.790; 95% CI: 0.671-0.931; P= 0.005), but not with PsA (IVW: OR: 0.845; 95% CI: 0.685-1.043; p= 0.117). The reverse MR analyses showed that no causal effects were observed in psoriasis and its two subtypes on LTL.

Conclusion: Our study suggested a potential causal effect of shortened LTL on the increased risk of psoriasis, especially PsV, providing LTL as a novel biomarker and therapeutic target for psoriasis.

Keywords: Mendelian randomization; leukocyte telomere length; psoriasis; inflammation; causal inference;
Copyright: © 2024 by Zhuo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Zhuo, H. Causal Association Between Leukocyte Telomere Length and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study. Journal of Public Health & Environment, 2024, 7, 245. doi:10.69610/j.phe.20240709
AMA Style
Zhuo H. Causal Association Between Leukocyte Telomere Length and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study. Journal of Public Health & Environment; 2024, 7(1):245. doi:10.69610/j.phe.20240709
Chicago/Turabian Style
Zhuo, Haitao 2024. "Causal Association Between Leukocyte Telomere Length and Psoriasis: A Two-Sample Bidirectional Mendelian Randomization Study" Journal of Public Health & Environment 7, no.1:245. doi:10.69610/j.phe.20240709

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