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Diagnostic accuracy of neutrophil lymphocyte ratio and platelet lymphocyte ratio for IVIG-resistance Kawasaki disease: an updated meta-analysis
1
Department of Pediatric Cardiology, Anhui Medical University Children's Medical Center, Hefei, Anhui, China.
2
The Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, China.
*
Author to whom correspondence should be addressed.
JPHE 2024 7(1):243; https://doi.org/10.69610/j.phe.20240605
Received: 16 April 2024 / Accepted: 22 May 2024 / Published Online: 5 June 2024
Abstract
Background: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) are biomarkers for the diagnosis and prognosis of many diseases. However, the diagnostic accuracy of IVIG resistant Kawasaki disease is still unclear. This study aims to evaluate the diagnostic value of NLR and PLR in IVIG resistant Kawasaki disease. Method: We used Pubmed, Embase, Web of science, CNKI and Google academic database to find all articles that met the inclusion criteria until January 5 2024.Result: After two independent researchers carefully read the title, abstract, and full text, five eligible studies were included in the study analysis, with a total of 3359 children included. The research results showed that the combined sensitivity and specificity were 0.57 (95% CI: 0.48-0.66) and 0.73 (95% CI: 0.67-0.78), respectively; The pooled positive likelihood ratio and Negative likelihood ratio were2.12（95%CI:1.91-2.34）and 0.58（95%CI:0.50-0.68）, respectively;The pooled DOR was 3.62（95% CI:2.99-4.39）;The area under the SROC curve (AUC) was 0.71 (95% CI: 0.67-0.75), indicating high diagnostic performance. Conclusion: This study analysis indicates that the PLR+NLR levels in children with Kawasaki disease can serve as an important parameter in the risk scoring system, with relatively high accuracy.
Copyright: © 2024 by Liu, Huang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Liu, Z.; Huang, X.; Zhao, S. Diagnostic accuracy of neutrophil lymphocyte ratio and platelet lymphocyte ratio for IVIG-resistance Kawasaki disease: an updated meta-analysis. Journal of Public Health & Environment, 2024, 7, 243. doi:10.69610/j.phe.20240605
AMA Style
Liu Z, Huang X, Zhao S. Diagnostic accuracy of neutrophil lymphocyte ratio and platelet lymphocyte ratio for IVIG-resistance Kawasaki disease: an updated meta-analysis. Journal of Public Health & Environment; 2024, 7(1):243. doi:10.69610/j.phe.20240605
Chicago/Turabian Style
Liu, ZhiYuan; Huang, XiaoBi; Zhao, Sheng 2024. "Diagnostic accuracy of neutrophil lymphocyte ratio and platelet lymphocyte ratio for IVIG-resistance Kawasaki disease: an updated meta-analysis" Journal of Public Health & Environment 7, no.1:243. doi:10.69610/j.phe.20240605
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