Issue 1 (June)

Internet-Based Cognitive Behavioral Therapy (iCBT) has emerged as a convenient and accessible intervention for depression and anxiety, offering evidence-based treatment delivered through online platforms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of iCBT in reducing symptoms of depression and anxiety and improving overall mental health outcomes. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of iCBT compared to control conditions (e.g., waitlist, face-to-face therapy) in targeting depressive and anxiety symptoms, functional impairment, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as program duration, therapist guidance, interactivity of the platform, and participant characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of iCBT for depression and anxiety.

Virtual Reality Exposure Therapy (VRET) has emerged as a promising intervention for Post-Traumatic Stress Disorder (PTSD), offering immersive and controlled environments for exposure to traumatic memories. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of VRET in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of VRET compared to control conditions (e.g., waitlist, traditional exposure therapy) in targeting symptoms of PTSD, including intrusive thoughts, avoidance behaviors, hyperarousal, and negative mood. Additionally, it examines potential moderators of treatment outcomes, such as the type of trauma, level of immersion, therapist involvement, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of VRET for PTSD.

Dialectical Behavior Therapy (DBT) has shown promise as an effective intervention for adolescents with Non-Suicidal Self-Injury (NSSI), providing skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing NSSI behaviors and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting frequency and severity of NSSI, suicidal ideation, emotion dysregulation, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, format (individual vs. group), therapist adherence, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of DBT for NSSI in adolescents.

Eye Movement Desensitization and Reprocessing (EMDR) therapy has gained recognition as an effective intervention for Post-Traumatic Stress Disorder (PTSD), utilizing bilateral stimulation to process traumatic memories and reduce associated symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR compared to control conditions (e.g., waitlist, cognitive behavioral therapy) in targeting symptoms of PTSD, including intrusive thoughts, avoidance behaviors, hyperarousal, and negative cognitions. Additionally, it examines potential moderators of treatment outcomes, such as treatment protocol variations, therapist training, session length, and participant characteristics (e.g., type of trauma, comorbidities), to better understand the factors influencing the effectiveness of EMDR for PTSD.

Acceptance and Commitment Therapy (ACT) has emerged as a promising intervention for chronic pain management, focusing on psychological flexibility and values-based action. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing pain intensity and improving overall functioning in individuals with chronic pain. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., treatment as usual, active interventions) in targeting pain-related outcomes, including pain severity, pain interference, physical functioning, and emotional distress. Additionally, it examines potential moderators of treatment outcomes, such as intervention format (individual vs. group), treatment duration, therapist involvement, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of ACT for chronic pain management.

Mindfulness-Based Cognitive Therapy (MBCT) has garnered attention as a promising intervention for preventing relapse in depression, combining cognitive therapy techniques with mindfulness practices. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBCT in reducing relapse rates and improving overall well-being in individuals with a history of depression. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBCT compared to control conditions (e.g., treatment as usual, maintenance antidepressant medication) in targeting relapse/recurrence of depressive episodes, symptoms of depression, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as participant adherence, length of follow-up, frequency of mindfulness practice, and participant characteristics (e.g., age, number of prior depressive episodes), to better understand the factors influencing the effectiveness of MBCT for relapse prevention in depression.

Interpersonal Psychotherapy (IPT) has been recognized as an effective intervention for Major Depressive Disorder (MDD), focusing on interpersonal issues and relationships. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving overall functioning in individuals with MDD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of depression, interpersonal functioning, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence, focus of interpersonal problems, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of IPT for MDD.

Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) has emerged as a leading intervention for addressing Post-Traumatic Stress Disorder (PTSD) symptoms in children and adolescents, integrating cognitive-behavioral techniques with trauma-specific components. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of TF-CBT in reducing PTSD symptoms and improving overall functioning in youth populations. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of TF-CBT compared to control conditions (e.g., waitlist, supportive therapy) in targeting PTSD symptoms, including re-experiencing, avoidance, negative alterations in cognition and mood, and hyperarousal. Additionally, it examines potential moderators of treatment outcomes, such as trauma type, treatment duration, parental involvement, and participant characteristics (e.g., age, gender, comorbidities), to better understand the factors influencing the effectiveness of TF-CBT for PTSD in children and adolescents.

Parent-Child Interaction Therapy (PCIT) has emerged as a leading intervention for addressing disruptive behavior disorders in children, focusing on improving parent-child interactions and reducing negative behaviors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PCIT in reducing disruptive behavior symptoms and improving parent-child relationships. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PCIT compared to control conditions (e.g., waitlist, treatment as usual) in targeting disruptive behaviors, including aggression, defiance, and conduct problems. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), therapist involvement, parent training intensity, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of PCIT for disruptive behavior disorders in children.

Applied Behavior Analysis (ABA) has been widely recognized as an effective intervention for addressing core symptoms of Autism Spectrum Disorder (ASD) in children, focusing on behavior modification and skill development. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ABA in improving communication, social interaction, and adaptive behavior in children with ASD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ABA compared to control conditions (e.g., treatment as usual, developmental interventions) in targeting ASD symptoms and associated impairments. Additionally, it examines potential moderators of treatment outcomes, such as treatment intensity, duration, therapist training, and participant characteristics (e.g., age, cognitive level), to better understand the factors influencing the effectiveness of ABA for ASD.

Cognitive Behavioral Therapy (CBT) has been established as a frontline intervention for Generalized Anxiety Disorder (GAD), targeting maladaptive thoughts and behaviors associated with excessive worry and anxiety. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CBT in reducing anxiety symptoms and improving overall functioning in individuals with GAD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CBT compared to control conditions (e.g., waitlist, medication, other psychotherapies) in targeting symptoms of anxiety, worry, and associated impairments. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), therapist involvement, treatment duration, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of CBT for GAD.

Dialectical Behavior Therapy (DBT) has gained recognition as a leading intervention for Borderline Personality Disorder (BPD), integrating cognitive-behavioral techniques with mindfulness and acceptance strategies. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of emotional dysregulation, impulsivity, self-harm, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, adherence to the DBT model, therapist characteristics, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD.

Eye Movement Desensitization and Reprocessing (EMDR) has emerged as a prominent intervention for treating Post-Traumatic Stress Disorder (PTSD), employing bilateral stimulation to process traumatic memories and alleviate associated symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR in reducing PTSD symptoms and improving overall well-being in individuals with PTSD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR compared to control conditions (e.g., waitlist, supportive therapy) in targeting PTSD symptoms, including re-experiencing, avoidance, negative alterations in cognition and mood, and hyperarousal. Additionally, it examines potential moderators of treatment outcomes, such as session length, therapist experience, treatment fidelity, and participant characteristics (e.g., trauma type, comorbidities), to enhance understanding of the factors influencing the effectiveness of EMDR for PTSD.

Acceptance and Commitment Therapy (ACT) has gained recognition as a promising intervention for treating depression, focusing on promoting psychological flexibility and values-based living. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing depressive symptoms and improving overall functioning in individuals with depression. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of depression, including sadness, anhedonia, guilt, and cognitive distortions. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), treatment duration, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for depression.

 Mindfulness-Based Stress Reduction (MBSR) has gained attention as an intervention for anxiety disorders, focusing on cultivating mindfulness skills to reduce symptoms of anxiety and enhance overall well-being. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing anxiety symptoms and improving quality of life in individuals with anxiety disorders. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual) in targeting symptoms of anxiety, including generalized anxiety, panic attacks, and social anxiety. Additionally, it examines potential moderators of treatment outcomes, such as intervention length, frequency of mindfulness practice, therapist guidance, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of MBSR for anxiety disorders.

Interpersonal Psychotherapy (IPT) has been recognized as an effective intervention for Major Depressive Disorder (MDD), focusing on interpersonal relationships and life events as triggers for depressive episodes. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving social functioning in individuals with MDD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, medication, other psychotherapies) in targeting symptoms of depression, including sadness, hopelessness, guilt, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment fidelity, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of IPT for MDD.

Psychodynamic therapy has long been considered a valuable intervention for personality disorders, addressing underlying conflicts and relational patterns that contribute to symptomatology. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of psychodynamic therapy in reducing symptom severity and improving overall functioning in individuals with personality disorders. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of psychodynamic therapy compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting symptoms associated with personality disorders, including interpersonal difficulties, affective instability, identity disturbance, and impulsivity. Additionally, it examines potential moderators of treatment outcomes, such as treatment length, therapist experience, treatment fidelity, and participant characteristics (e.g., specific personality disorder diagnosis, comorbidities), to better understand the factors influencing the effectiveness of psychodynamic therapy for personality disorders.

Family therapy has been recognized as a valuable intervention for adolescent conduct disorder, targeting family dynamics and communication patterns that contribute to behavioral problems. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of family therapy in reducing conduct disorder symptoms and improving family functioning in adolescents. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of family therapy compared to control conditions (e.g., treatment as usual, individual therapy) in targeting conduct disorder symptoms, including aggression, rule-breaking behavior, and defiance. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, family involvement, and adolescent characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of family therapy for adolescent conduct disorder.

Cognitive remediation therapy (CRT) has emerged as a promising intervention for schizophrenia, aiming to improve cognitive functioning and enhance daily functioning in individuals with the disorder. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CRT in improving cognitive deficits and functional outcomes in individuals with schizophrenia. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CRT compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting cognitive domains such as attention, memory, executive function, and social cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity, adjunctive interventions, and participant characteristics (e.g., age, duration of illness), to better understand the factors influencing the effectiveness of CRT for schizophrenia.

Dialectical Behavior Therapy (DBT) has shown promise as an intervention for eating disorders, addressing both the underlying emotional dysregulation and maladaptive behaviors associated with disordered eating. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing eating disorder symptoms and improving overall well-being in individuals with eating disorders. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of eating disorders, including restrictive eating, binge eating, purging behaviors, and body image disturbance. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence, treatment setting, and participant characteristics (e.g., age, diagnosis subtype), to better understand the factors influencing the effectiveness of DBT for eating disorders.

Exposure and Response Prevention (ERP) therapy has emerged as a leading intervention for Obsessive-Compulsive Disorder (OCD), targeting the core symptoms of obsessions and compulsions through systematic exposure to feared stimuli and prevention of ritualistic behaviors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ERP in reducing OCD symptoms and improving overall functioning in individuals with OCD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ERP compared to control conditions (e.g., waitlist, medication, other psychotherapies) in targeting symptoms of OCD, including obsessions, compulsions, and associated distress. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, symptom severity), to better understand the factors influencing the effectiveness of ERP for OCD.

Acceptance and Commitment Therapy (ACT) has garnered attention as a promising intervention for Generalized Anxiety Disorder (GAD), focusing on acceptance of internal experiences and commitment to value-driven action. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing GAD symptoms and improving overall functioning in individuals with GAD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual, other psychotherapies) in targeting symptoms of GAD, including excessive worry, somatic symptoms, and avoidance behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), treatment duration, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for GAD.

Mindfulness-Based Cognitive Therapy (MBCT) has emerged as a promising intervention for individuals with recurrent depression, combining elements of cognitive therapy with mindfulness practices to prevent relapse and reduce depressive symptoms. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBCT in reducing depressive relapse and improving overall well-being in individuals with recurrent depression. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBCT compared to control conditions (e.g., treatment as usual, maintenance antidepressants, other psychotherapies) in targeting depressive relapse rates, depressive symptoms severity, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, frequency of mindfulness practice, therapist guidance, and participant characteristics (e.g., history of depression, comorbidities), to better understand the factors influencing the effectiveness of MBCT for recurrent depression.

Interpersonal Therapy (IPT) has shown promise as an intervention for Social Anxiety Disorder (SAD), addressing interpersonal difficulties and social skills deficits that contribute to anxiety in social situations. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing social anxiety symptoms and improving overall functioning in individuals with SAD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, medication, other psychotherapies) in targeting symptoms of SAD, including fear of social evaluation, avoidance behavior, and impairment in social and occupational functioning. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, symptom severity), to better understand the factors influencing the effectiveness of IPT for SAD.

Schema Therapy has emerged as a promising intervention for Borderline Personality Disorder (BPD), targeting underlying maladaptive schemas and dysfunctional coping strategies that contribute to symptom severity and impairment in interpersonal relationships. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of Schema Therapy in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of Schema Therapy compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of BPD, including affective instability, identity disturbance, interpersonal difficulties, and impulsivity. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of Schema Therapy for BPD.

Eye Movement Desensitization and Reprocessing (EMDR) therapy has gained recognition as a leading intervention for Post-Traumatic Stress Disorder (PTSD), targeting traumatic memories and associated symptoms through bilateral stimulation. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR therapy in reducing PTSD symptoms and improving overall functioning in individuals with PTSD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR therapy compared to control conditions (e.g., waitlist, other psychotherapies) in targeting symptoms of PTSD, including re-experiencing, avoidance, hyperarousal, and negative alterations in mood and cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, frequency of sessions, therapist experience, and participant characteristics (e.g., type of trauma, comorbidities), to better understand the factors influencing the effectiveness of EMDR therapy for PTSD.

Cognitive Processing Therapy (CPT) has emerged as a leading evidence-based intervention for military-related Post-Traumatic Stress Disorder (PTSD), targeting maladaptive cognitions and beliefs associated with traumatic experiences. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CPT in reducing PTSD symptoms and improving overall functioning in military veterans and active-duty service members with PTSD. Through a comprehensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CPT compared to control conditions (e.g., waitlist, treatment as usual, other psychotherapies) in targeting symptoms of military-related PTSD, including re-experiencing, avoidance, hyperarousal, and negative alterations in mood and cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., combat exposure, deployment history), to better understand the factors influencing the effectiveness of CPT for military-related PTSD.

Dialectical Behavior Therapy (DBT) has emerged as a leading intervention for Borderline Personality Disorder (BPD), targeting emotion dysregulation and maladaptive behaviors through a combination of cognitive-behavioral techniques and mindfulness skills. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting symptoms of BPD, including affective instability, impulsivity, interpersonal difficulties, and identity disturbance. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD.

Prolonged Exposure Therapy (PE) has emerged as a prominent intervention for combat-related Post-Traumatic Stress Disorder (PTSD), targeting avoidance behaviors and facilitating emotional processing of traumatic memories. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PE in reducing PTSD symptoms and improving overall functioning in military veterans and active-duty service members with combat-related PTSD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PE compared to control conditions (e.g., waitlist, treatment as usual, other psychotherapies) in targeting symptoms of combat-related PTSD, including re-experiencing, avoidance, hyperarousal, and negative alterations in mood and cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., severity of trauma exposure, deployment history), to better understand the factors influencing the effectiveness of PE for combat-related PTSD.

Acceptance and Commitment Therapy (ACT) has gained recognition as an effective intervention for Generalized Anxiety Disorder (GAD), focusing on enhancing psychological flexibility and promoting values-based living. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing GAD symptoms and improving overall functioning in individuals with GAD. Through an extensive literature review, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual, other psychotherapies) in targeting symptoms of GAD, including excessive worry, physical tension, cognitive disturbances, and avoidance behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, treatment format (individual vs. group), and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for GAD.