Issue 2 (December)

Interpersonal Psychotherapy (IPT) has been recognized as a promising treatment for Major Depressive Disorder (MDD). This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving overall functioning in individuals with MDD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of MDD, including depressed mood, anhedonia, guilt, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, frequency of sessions, therapist experience, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of IPT for MDD.

Motivational Interviewing (MI) has emerged as a widely used approach for treating Substance Use Disorders (SUDs). This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MI in reducing substance use and improving overall treatment outcomes in individuals with SUDs. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MI compared to control conditions (e.g., treatment as usual, standard counseling) in targeting substance use behaviors, including frequency, severity, and abstinence rates. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, therapist proficiency, level of motivation, and substance type, to better understand the factors influencing the effectiveness of MI for SUDs.

Acceptance and Commitment Therapy (ACT) has shown promise as a treatment approach for chronic pain management. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing pain intensity and improving overall functioning in individuals with chronic pain conditions. Through an extensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., treatment as usual, waitlist) in targeting pain-related outcomes, including pain severity, pain interference, disability, and psychological distress. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, format (individual vs. group), therapist involvement, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of ACT for chronic pain management.

Internet-Delivered Cognitive Behavioral Therapy (iCBT) has emerged as a convenient and accessible treatment option for anxiety disorders. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of iCBT in reducing anxiety symptoms and improving overall functioning in individuals with various anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of iCBT compared to control conditions (e.g., waitlist, treatment as usual) in targeting anxiety-related outcomes, such as anxiety severity, worry, avoidance behaviors, and impairment. Additionally, it examines potential moderators of treatment outcomes, such as program duration, therapist support level, treatment adherence, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of iCBT for anxiety disorders.

Mindfulness-Based Stress Reduction (MBSR) has gained popularity as a complementary approach for managing various chronic health conditions. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing symptoms and improving quality of life in individuals with chronic health conditions such as chronic pain, fibromyalgia, hypertension, and diabetes. Through an exhaustive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual) in targeting health-related outcomes, including pain severity, physical functioning, psychological distress, and disease management. Additionally, it examines potential moderators of treatment outcomes, such as program duration, frequency of sessions, participant adherence, and baseline health status, to better understand the factors influencing the effectiveness of MBSR for chronic health conditions.

Schema Therapy (ST) has emerged as a promising treatment approach for Borderline Personality Disorder (BPD). This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ST in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ST compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting core symptoms of BPD, including affect dysregulation, unstable relationships, identity disturbance, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, mode of delivery (individual vs. group), therapist expertise, and participant characteristics (e.g., trauma history, comorbidities), to better understand the factors influencing the effectiveness of ST for BPD.

Dialectical Behavior Therapy (DBT) has been increasingly utilized as a treatment approach for adolescents with emotional dysregulation and related difficulties. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing emotional dysregulation symptoms and improving overall functioning in adolescents. Through an extensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, supportive therapy) in targeting core symptoms of emotional dysregulation, including mood instability, impulsivity, self-harm behaviors, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, mode of delivery (individual vs. group), therapist qualifications, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of DBT for adolescents with emotional dysregulation.

Family-Based Therapy (FBT), also known as the Maudsley Approach, has been recognized as a leading treatment for adolescents with eating disorders such as anorexia nervosa and bulimia nervosa. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of FBT in reducing eating disorder symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of FBT compared to control conditions (e.g., individual therapy, supportive therapy) in targeting core symptoms of eating disorders, including restrictive eating, binge eating, purging behaviors, and weight restoration. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, family involvement, therapist expertise, and participant characteristics (e.g., age, duration of illness), to better understand the factors influencing the effectiveness of FBT for adolescents with eating disorders.

Prolonged Exposure Therapy (PE) has been widely utilized as a leading treatment for Posttraumatic Stress Disorder (PTSD) in veterans. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PE in reducing PTSD symptoms and improving overall functioning in veterans. Through an extensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PE compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of PTSD, including intrusive thoughts, avoidance behaviors, negative cognitions, and hyperarousal. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist experience, session frequency, and participant characteristics (e.g., combat exposure, comorbidities), to better understand the factors influencing the effectiveness of PE for PTSD in veterans.

Acceptance and Commitment Therapy (ACT) has gained attention as a potential treatment for insomnia disorder, offering a unique approach that targets underlying processes contributing to sleep difficulties. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing insomnia symptoms and improving sleep quality. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., sleep hygiene education, relaxation techniques) in targeting insomnia-related outcomes, including sleep onset latency, wake after sleep onset, total sleep time, and sleep efficiency. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, mode of delivery (individual vs. group), therapist involvement, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for insomnia disorder.

Mindfulness-Based Cognitive Therapy (MBCT) has shown promise as a psychological intervention for preventing depressive relapse in individuals with a history of recurrent depression. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBCT in reducing depressive symptoms and preventing relapse/recurrence of depression. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBCT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting depression-related outcomes, including depressive symptom severity, relapse rates, and quality of life. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, frequency of sessions, participant adherence, and baseline characteristics (e.g., number of prior depressive episodes, severity of current symptoms), to better understand the factors influencing the effectiveness of MBCT for depression relapse prevention.

Cognitive Behavioral Therapy (CBT) has been widely recognized as the first-line treatment for Social Anxiety Disorder (SAD) in adolescents. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CBT in reducing social anxiety symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CBT compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of SAD, including fear of negative evaluation, avoidance behaviors, and social functioning. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, format (individual vs. group), therapist involvement, and participant characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of CBT for SAD in adolescents.

Eye Movement Desensitization and Reprocessing (EMDR) therapy has emerged as a promising intervention for treating Posttraumatic Stress Disorder (PTSD) in children and adolescents. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of EMDR therapy in reducing PTSD symptoms and improving overall functioning in this population. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of EMDR therapy compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of PTSD, including intrusive thoughts, avoidance behaviors, hyperarousal, and negative alterations in cognition and mood. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session frequency, therapist expertise, and participant characteristics (e.g., age, type of trauma), to better understand the factors influencing the effectiveness of EMDR therapy for PTSD in children and adolescents.

Play therapy has been widely utilized as an intervention for children with behavioral and emotional difficulties, offering a developmentally appropriate approach to address their needs. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of play therapy in reducing behavioral and emotional problems and improving overall functioning in children. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of play therapy compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of behavioral and emotional problems, including aggression, anxiety, depression, and social withdrawal. Additionally, it examines potential moderators of treatment outcomes, such as therapist training and experience, session frequency, and participant characteristics (e.g., age, presenting problems), to better understand the factors influencing the effectiveness of play therapy for children with behavioral and emotional difficulties.

Parent-Child Interaction Therapy (PCIT) has emerged as a leading intervention for young children with disruptive behavior disorders, providing a structured and empirically supported approach to improving parent-child interactions and reducing problem behaviors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of PCIT in reducing disruptive behavior symptoms and improving parent-child relationships in young children. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of PCIT compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of disruptive behavior disorders, including oppositional behavior, aggression, defiance, and noncompliance. Additionally, it examines potential moderators of treatment outcomes, such as therapist fidelity, parent involvement, session format (individual vs. group), and child characteristics (e.g., age, severity of symptoms), to better understand the factors influencing the effectiveness of PCIT for young children with disruptive behavior disorders.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adults, offering a comprehensive approach to addressing the core symptoms and functional impairments associated with the disorder. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adults. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, impulsivity, interpersonal difficulties, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, therapist adherence, participant characteristics (e.g., comorbidities, severity of symptoms), and session format (individual vs. group), to better understand the factors influencing the effectiveness of DBT for BPD in adults.

Mindfulness-Based Stress Reduction (MBSR) has gained attention as a potential intervention for Generalized Anxiety Disorder (GAD) in adults, offering a holistic approach to reducing anxiety symptoms and improving overall well-being. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing anxiety symptoms and enhancing psychological functioning in adults with GAD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of GAD, including excessive worry, somatic symptoms, and cognitive distortions. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session frequency, participant adherence, and baseline characteristics (e.g., severity of anxiety, comorbidities), to better understand the factors influencing the effectiveness of MBSR for GAD in adults.

Cognitive Remediation Therapy (CRT) has emerged as a promising intervention for addressing cognitive deficits in individuals with schizophrenia, aiming to improve cognitive functioning and functional outcomes. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CRT in enhancing cognitive abilities and functional outcomes in individuals with schizophrenia. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CRT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting cognitive domains such as attention, memory, executive function, and social cognition. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, session frequency, therapist involvement, and participant characteristics (e.g., duration of illness, symptom severity), to better understand the factors influencing the effectiveness of CRT for schizophrenia.

Acceptance and Commitment Therapy (ACT) has emerged as a promising intervention for Major Depressive Disorder (MDD) in adults, focusing on fostering psychological flexibility and promoting valued living. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing depressive symptoms and improving overall functioning in adults with MDD. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, treatment as usual) in targeting core symptoms of depression, including low mood, anhedonia, cognitive distortions, and functional impairment. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session frequency, therapist competence, and participant characteristics (e.g., comorbidities, treatment history), to better understand the factors influencing the effectiveness of ACT for MDD in adults.

Exposure Therapy (ET) has been recognized as a first-line treatment for Post-Traumatic Stress Disorder (PTSD) in military veterans, aiming to reduce symptoms of re-experiencing, avoidance, hyperarousal, and negative alterations in mood and cognition. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ET in reducing PTSD symptoms and improving overall functioning in military veterans. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ET compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of PTSD. Additionally, it examines potential moderators of treatment outcomes, such as treatment format (individual vs. group), length of exposure, therapist expertise, and participant characteristics (e.g., combat exposure, comorbidities), to better understand the factors influencing the effectiveness of ET for PTSD in military veterans.

Interpersonal Psychotherapy (IPT) has emerged as a promising intervention for depression in adolescents, focusing on improving interpersonal relationships and addressing psychosocial stressors. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of IPT in reducing depressive symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of IPT compared to control conditions (e.g., waitlist, supportive therapy) in targeting core symptoms of depression, including low mood, anhedonia, irritability, and interpersonal difficulties. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, session format (individual vs. group), therapist expertise, and participant characteristics (e.g., age, gender), to better understand the factors influencing the effectiveness of IPT for depression in adolescents.

 Family-Based Therapy (FBT), also known as Maudsley Approach, has emerged as a leading intervention for eating disorders in adolescents, focusing on empowering families to support their child's recovery. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of FBT in reducing eating disorder symptoms and improving overall functioning in adolescents. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of FBT compared to control conditions (e.g., individual therapy, treatment as usual) in targeting core symptoms of eating disorders, including restrictive eating, binge eating, purging behaviors, and body image dissatisfaction. Additionally, it examines potential moderators of treatment outcomes, such as family involvement, therapist training, treatment duration, and participant characteristics (e.g., age, duration of illness), to better understand the factors influencing the effectiveness of FBT for eating disorders in adolescents.

Mindfulness-Based Interventions (MBIs) have gained recognition as effective approaches for managing chronic pain, offering holistic strategies to alleviate suffering and improve quality of life. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBIs in reducing pain intensity and enhancing pain-related outcomes in individuals with chronic pain conditions. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBIs compared to control conditions (e.g., treatment as usual, active control interventions) in targeting pain severity, pain interference, physical functioning, and psychological distress. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session format (group vs. individual), mindfulness practice intensity, and participant characteristics (e.g., pain duration, comorbidities), to better understand the factors influencing the effectiveness of MBIs for chronic pain management.

Cognitive Behavioral Therapy for Insomnia (CBT-I) has been established as the first-line treatment for chronic insomnia, offering effective strategies to improve sleep quality and quantity. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of CBT-I in reducing insomnia severity and improving sleep-related outcomes in adults. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of CBT-I compared to control conditions (e.g., waitlist, sleep hygiene education) in targeting sleep latency, wake after sleep onset, total sleep time, sleep efficiency, and subjective sleep quality. Additionally, it examines potential moderators of treatment outcomes, such as treatment components (e.g., sleep restriction, stimulus control), treatment format (individual vs. group), therapist involvement, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of CBT-I for insomnia in adults.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adolescents, offering comprehensive skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adolescents. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, interpersonal difficulties, impulsivity, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity of therapy, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD in adolescents.

Dialectical Behavior Therapy (DBT) has emerged as a leading treatment for Borderline Personality Disorder (BPD) in adolescents, offering comprehensive skills training and emotion regulation techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of DBT in reducing BPD symptoms and improving overall functioning in adolescents. Through a thorough review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of DBT compared to control conditions (e.g., treatment as usual, active control interventions) in targeting core symptoms of BPD, including emotional dysregulation, interpersonal difficulties, impulsivity, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, intensity of therapy, therapist adherence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of DBT for BPD in adolescents.

Acceptance and Commitment Therapy (ACT) has gained prominence as an effective intervention for anxiety disorders in adults, emphasizing acceptance of distressing thoughts and feelings and commitment to values-based action. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ACT in reducing anxiety symptoms and improving overall functioning in adults with anxiety disorders. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ACT compared to control conditions (e.g., waitlist, active control interventions) in targeting core symptoms of anxiety, including generalized anxiety, social anxiety, panic attacks, and specific phobias. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, session format (individual vs. group), therapist competence, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ACT for anxiety disorders in adults.

Group therapy has long been recognized as a valuable intervention for individuals with substance use disorders, offering a supportive environment for peer interaction and shared experiences. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of group therapy in reducing substance use and improving overall functioning in individuals with substance use disorders. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of group therapy compared to control conditions (e.g., individual therapy, treatment as usual) in targeting substance use frequency, severity of dependence, cravings, and psychosocial functioning. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, group size, therapist involvement, and participant characteristics (e.g., substance of abuse, comorbidities), to better understand the factors influencing the effectiveness of group therapy for substance use disorders.

 Mindfulness-Based Stress Reduction (MBSR) has gained popularity as an intervention to reduce stress and enhance well-being, particularly among healthcare professionals who face high levels of occupational stress. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of MBSR in reducing stress and improving overall well-being in healthcare professionals. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of MBSR compared to control conditions (e.g., waitlist, active control interventions) in targeting stress levels, burnout, compassion fatigue, and job satisfaction. Additionally, it examines potential moderators of treatment outcomes, such as intervention duration, frequency of mindfulness practice, instructor qualifications, and participant characteristics (e.g., profession, years of experience), to better understand the factors influencing the effectiveness of MBSR for stress reduction in healthcare professionals.

Schema Therapy (ST) has emerged as a promising intervention for Borderline Personality Disorder (BPD), targeting maladaptive schemas and core emotional needs. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy of ST in reducing BPD symptoms and improving overall functioning in individuals with BPD. Through a comprehensive review of the literature, the meta-analysis synthesizes effect sizes from RCTs assessing the effectiveness of ST compared to control conditions (e.g., treatment as usual, other psychotherapies) in targeting core symptoms of BPD, including emotional dysregulation, identity disturbance, interpersonal difficulties, and self-harm behaviors. Additionally, it examines potential moderators of treatment outcomes, such as treatment duration, mode of delivery (individual vs. group), therapist experience, and participant characteristics (e.g., age, comorbidities), to better understand the factors influencing the effectiveness of ST for BPD.

This article are supported by WELI Scientific.