Vaccines and Vaccine Development: Protection against Infectious Diseases
Abstract
Vaccines have been instrumental in preventing and controlling infectious diseases, saving millions of lives worldwide. This paper provides an overview of vaccines and vaccine development, emphasizing their critical role in public health. Key topics include the principles of vaccination, including active and passive immunity, as well as the types of vaccines, such as live attenuated, inactivated, subunit, and mRNA vaccines. Additionally, the paper discusses the process of vaccine development, from preclinical studies and clinical trials to regulatory approval and post-marketing surveillance. Furthermore, the paper examines challenges and controversies surrounding vaccines, including vaccine hesitancy, safety concerns, and the emergence of vaccine-resistant pathogens. By synthesizing evidence from epidemiological studies, vaccine trials, and public health interventions, this paper aims to underscore the importance of vaccines in disease prevention and advocate for vaccination as a cornerstone of global health initiatives.
Share and Cite
Article Metrics
References
- Plotkin, S. A., et al. (2017). A short history of vaccination. In Vaccines (pp. 1-13). Elsevier.
- Andre, F. E., et al. (2008). Vaccination greatly reduces disease, disability, death and inequity worldwide. Bulletin of the World Health Organization, 86(2), 81-160.
- Rappuoli, R., & Pizza, M. (2015). Vaccines, new opportunities for a new society. Proceedings of the National Academy of Sciences, 112(38), 11671-11672.
- Orenstein, W. A., et al. (2016). Vaccines in the 21st century: the critical role of immunization in achieving global health. Vaccine, 34(52), 6681-6684.
- Hotez, P. J., et al. (2019). Vaccines and neglected tropical diseases: from development to access. PLoS Neglected Tropical Diseases, 13(6), e0006809.
- Bloom, D. E., et al. (2018). Priorities for vaccine research. Disease Control Priorities (Third Edition), 5, 457-473.
- Plotkin, S. A. (2014). Vaccines: correlates of vaccine-induced immunity. Clinical Infectious Diseases, 47(3), 401-409.
- Offit, P. A., et al. (2019). Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics, 112(Supplement 1), 1394-1401.